Long-term and inappropriate use of antibiotics has led to the development of antimicrobial resistance (AMR). However, during the process, a lack of specific targeting of antibiotics leads to low efficacy caused by inadequate drug concentration at sites of infection, in addition to off-target effects such as increased adverse toxicity towards healthy cells. The use of antibodies or bacteriophages to fight the pathogen can be another strategy that is well-documented. Targeting the pathogen and delivering a toxic payload creates two resistance pathways. Ī few approaches to narrower-spectrum antibiotics and rapid diagnostics are being discussed, as are the theoretical benefits and drawbacks of this new approach to bacterial infectious diseases. Recent figures show that 1.2 million deaths were caused by resistant bacterial infections in 2019 and 4.95 million in 2020. When clinically significant resistance has developed, it has been met with either the introduction of new antibiotic classes or the modification of existing antibiotic classes that have low rates of cross-resistance. Antimicrobial resistance (AMR) has been observed as a natural occurrence ever since penicillin was first used in the 1940s. However, several problems related to antibiotics continue to rise and become a limitation in the effective treatment of infectious diseases. Antibiotics inhibit cell wall or protein synthesis, damage bacterial membranes, cause interior substance loss, and more. Since they were discovered early in the 1920s and were introduced in the 1940s, antibiotics have played an important role in eradicating infectious diseases. The threat posed by infectious diseases necessitates research into effective responses to medication. According to WHO data in 2020, lower respiratory infections were the fourth leading cause of death worldwide. Globally, the top three causes of death are cardiovascular (ischemic heart disease and stroke), respiratory (chronic obstructive pulmonary disease and lower respiratory infections), and neonatal conditions (birth asphyxia, birth trauma, neonatal sepsis and infections, and preterm birth complications).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |